Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial

Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial

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Abstract Background Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemotherapy (CC, 15.4 vs.4.07 months).We conducted an economic evaluation of pralatrexate from a societal perspective in Korea based on data from bostik universal primer pro the PROPEL phase II study.

Methods Using a Markov model with a weekly cycle, we simulated the experience of patients with R/R PTCL receiving pralatrexate or CC for 15 years.The model consists of five health states; initial treatment, treatment pause, subsequent treatment, stem cell transplantation (SCT) success, and death.Comparative effectiveness was based on PROPEL phase II single-arm study and its matched historical control analysis.Costs included drug, drug administration, monitoring, adverse event management, and SCT costs.Results The incremental cost-effectiveness ratio of the base case was $39,153 per quality-adjusted life-year (QALY) gained.

The results of one-way sensitivity analysis ranged from $33,949 to $51,846 per QALY gained, which remained within an implicit willingness-to-pay (WTP) threshold of anticancer drugs in Korea.Conclusions Pralatrexate is a cost-effective intervention with improved OS and incremental costs within the WTP limit.Pralatrexate could click here function as a new therapeutic option for patients suffering from life-threatening R/R PTCL.